Code access security error
The .NET Framework provides a security mechanism called code access security, that allows code to be trusted to varying degrees depending on where the code originates. If you experience an unhandled exception when trying to start PrintShop Mail from an untrusted location like a network share, try copying the program files to a trusted location.
Current status: We are working on an update to PrintShop Mail in order to improve error feedback for this specific situation.
For more information see Code Access Security on MSDN.microsoft.com